Gab2在宫颈癌组织中的表达及临床意义
[摘要]目的 探讨Gab2在宫颈癌组织中的表达情况与临床病理特征的相关性。方法 随机选取遵义医学院附属医院病理科保存的2012年1月～2013年12月经病理确诊的80例宫颈癌组织标本及20例正常宫颈组织标本，分别采用免疫组织化学实验方法检测Gab2在宫颈癌组织及正常宫颈组织中的表达情况，并结合临床病理资料进行统计分析。结果 Gab2蛋白在80例宫颈癌组织中的阳性表达率为58.75%（47/80），而在20例正常宫颈组织中仅3例呈弱阳性表达，阳性表达率为0.00%，两组结果比较差异有统计学意义（P<0.05）。在宫颈癌组织中，Gab2蛋白的表达水平与淋巴结转移呈正相关（P<0.05），与年龄、肿瘤大小、组织学分级及FIGO分期无显著相关性（P>0.05）。Gab2高表达患者的复发转移率显著高于Gab2低表达患者（P=0.001）。结论 Gab2可能在宫颈癌发生和进展中起着重要作用，可能具有作为宫颈癌预后判断标志物的潜能。
[关键词]宫颈癌；Gab2；免疫组织化学；淋巴结转移
[中图分类号] R737.33 [文献标识码] A [文章编号] 1674-4721（2018）2（b）-0008-03
Expression and clinical significance of Gab2 in cervical cancer tissue
ZHANG Yan CHENG Long DUAN Wen-li LIU Xiao ZHOU Hang
Department of Abdominal Oncology，Affiliated Hospital of Zunyi Medical College，Guizhou Province，Zunyi 563000，China
[Abstract]Objective To investigate the correlation between the expression of Gab2 in cervical cancer tissue and the clinical pathological features.Methods 80 cervical cancer specimens definitely diagnosed by pathology from January 2012 to December 2013 and 20 normal cervical tissue specimens which were stored in our Department of Pathology were randomly selected in our hospital.The immunohistochemical method was used to detect the expression of Gab2 in cervical cancer tissues and normal cervical tissues，and was statistically analyzed together with the clinical and pathological data.Results The positive expression rate of Gab2 in 80 cervical cancer tissues was 58.75% （47/80），and in the 20 normal cervical tissues，only 3 cases were presented with weak positive expression.The rate of positive expression was 0%，which was displayed a statistical difference （P<0.05）.The expression level of Gab2 protein in cervical cancer tissues was positively correlated with lymph node metastasis （P<0.05），but didn’t present with great correlation with age，size of tumor，histological grading or FIGO stage （P>0.05）.The recurrence and metastasis rate in patients with high Gab2 expression was significantly higher than that of low expression of Gab2 （P=0.001）.Conclusion Gab2 may play an important role in the occurrence and progression of cervical cancer，and may be considered as a potential for prognostic marker of cervical cancer.
[Key words]Cervical cancer；Gab2；Immunohistochemistry；Lymph node metastasis
宫颈癌（cervical cancer，CC）在我国女性生殖道恶性肿瘤中发病率位居第一[1]，淋巴结转移发生率高、局部复发和远处转移是治疗失败的主要原因，严重影响着女性的身心健康。Gab2（Grb2-associated binding protein 2，Gab2）屬于Gabs蛋白家族（Grb2-associated binder family proteins）的多位点衔接蛋白[2]，具有潜在的原癌基因特性，在多种恶性肿瘤的发生、发展中有着重要作用，如在肺癌、乳腺癌及结直肠癌等肿瘤中显著表达[3-5]。然而，有关Gab2蛋白在宫颈癌中的表达模式和临床意义尚不清楚。本实验通过免疫组织化学法检测Gab2在宫颈癌及正常宫颈组织中的表达水平及其与临床病理特征的关系，评估Gab2在宫颈癌预后判断标志物的潜在临床价值，现报道如下。