药物干预对晚期肿瘤合并抑郁状态患者生活质量的影响
[摘要]目的 探讨药物干预对晚期肿瘤合并抑郁状态患者生活质量的影响。方法 选择2012年4月～2016年4月在我院诊断治疗的晚期肿瘤合并标准抑郁状态的患者214例，采用随机数字表法将其分为实验组112例，对照组102例，对照组患者进行常规的抗肿瘤治疗，实验组在对照组治疗基础上，每日早、午饭后各予1片氟哌噻吨美利曲辛片治疗，>60岁的患者每日早饭后服用1片氟哌噻吨美利曲辛片。1、2、3、4周后再次用QOL量表进行评分。结果 实验组患者第4周后数值高于第0组，差异有统计学意义（P<0.05），实验组患者治疗后QOL评分高于对照组，差异均有统计学意义（P<0.05），实验组的副作用高于对照组（P<0.05）。结论 晚期肿瘤合并抑郁状态联合应用氟哌噻吨美利曲辛药物干预，可提高晚期肿瘤合并抑郁状态患者的生活质量，无明显不良反应，值得临床应用。
[关键词]晚期肿瘤；抑郁状态；氟哌噻吨美利曲辛片
[中图分类号] R732 [文献标识码] A [文章编号] 1674-4721（2018）2（b）-0080-03
Influence of drug intervention on the quality of life in patients with advanced tumor and depression
GAO Jin-suo WANG Jian-bing LIU Wei-wei YANG Jin-zhu
Department of Oncology，the Third People′s Hospital of Hefei City in Anhui Province，Hefei 230022，China
[Abstract]Objective To investigate the effect of drug intervention on quality of life in patients with advanced tumor and depression.Methods From April 2012 to April 2016，214 patients with advanced tumor complicated with standard depression were selected and randomly divided into experimental group（112 cases），control group（102 cases）and control group （102cases）.The patients in the experimental group were treated with conventional anti-tumor therapy.on the basis of the treatment of the control group，the patients in the experimental group were treated with one tablet of Flupentixol Melitracen every morning and one tablet of Flupentixol Melitracen every day after lunch，and the patients>60 years old were treated with 1 tablet of Flupentixol Melitracen every day after breakfast. After 1，2，3 and 4 weeks，QOL scale was used to score again.Results The QOL score of the experimental group at week 1-4 was significantly higher than that before treatment （P<0.05）.The QOL score of the experimental group was higher than that of the control group（P<0.05），and the side effect of the experimental group was higher than that of the control group （P<0.05）.Conclusion Drug intervention of Flupentixol Melitracen can improve QOL of patients with advanced tumor combined with depression，and without obvious adverse reactions，is worthy of clinical application.
[Key words]Advanced tumor；Depression；Flupentixol and Melitracen Tablets
目前的醫学模式是生物-心理-社会医学模式 [1]。随着医学模式的转变，生活质量（quality of life，QOL） 的概念渐渐引入医学研究中[2]。近20 年来，QOL 己被广泛应用于各种慢性病防治，特别是肿瘤患者治疗效果的评价上，成为癌症治疗临床试验的终点之一[3]。晚期肿瘤患者合并抑郁症比例高，危害患者的生活质量，严重的抑郁症甚至是癌症患者自杀倾向[4]。临床医师对晚期肿瘤合并抑郁症的关注也较少。我们应用汉密尔顿抑郁量表（HRSD）及QOL量表，对晚期患者进行调查，对符合诊断标准的患者，选用氟哌噻吨美利曲辛片对晚期肿瘤患者合并有抑郁状态患者进行药物干预，观察晚期患者生活质量的改变，现报道如下。